pharmacology

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Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere interacting agents, apoptosis inducers, and anti-invasive agents. This book presents an authoritative overview of existing molecular targeted therapies, their relevance and role for specific tumors, and their clinical efficacy and impact on patient treatment.

Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere interacting agents, apoptosis inducers, and anti-invasive agents. This book presents an authoritative overview of existing molecular targeted therapies, their relevance and role for specific tumors, and their clinical efficacy and impact on patient treatment.

The definitive pocket reference for convenient everyday use.
This invaluable clinical companion begins with an overview of the general principles relevant to the safe and effective use of psychotropic medications. Subsequent chapters focus on the major classes of psychotropic medications and the disorders for which they are prescribed—with the caveat that the nomenclature is somewhat artificial because, for example, many antidepressant medications are also used to treat anxiety disorders.
Updates for this edition in every drug class ensure ready access to information on new drugs and new findings.

Antidepressants—Presents clinically relevant information for selective serotonin reuptake inhibitors, bupropion, venlafaxine, duloxetine, mirtazapine, as well as tricyclic antidepressants and monoamine oxidase inhibitors, including details on choosing one antidepressant over another and discontinuing or switching medications. Updated with new information on the possible risk of increased suicidality and other potential side effects.
Anxiolytics, sedatives, and hypnotics—Discusses the use of benzodiazepines, zolpidem, and zaleplon, and ramelteon for the treatment of insomnia as well as diagnosis-specific guidelines for the use of antidepressants in the treatment of anxiety disorders.

Antipsychotics—Describes the properties common to most antipsychotics, focusing on atypical antipsychotics (clozapine, risperidone, olanzapine, quetiapine, ziprasidone), now used as first-line agents. New in this edition: the latest findings on safety and efficacy, and on the use of antipsychotic agents in bipolar disorder.

Mood stabilizers—-Details the use of lithium, valproate, carbamazepine, lamotrigine, and other anticonvulsants in stabilizing mood oscillations, and expands on the use of antipsychotics for treating bipolar disorder. With new information on the treatment of mania and mixed episodes.

Stimulants—Covers the clinical use, contraindications, risks and side effects, dosing strategies, and monitoring guidelines for methylphenidate hydrochloride, dextroamphetamine, pemoline, and modafinil, used to treat attention-deficit/hyperactivity disorder in children and adolescents, narcolepsy, and (potentially) treatment-resistant depression and cognitive impairment in adults.

Cognitive enhancers—Discusses the clinical use, drug interactions, and side effects of the cholinesterase inhibitors tacrine, donepezil, rivastigmine, and galantamine, which preserve functioning and slow further deterioration in the pharmacological management of cognitive impairment in mild-to-moderate dementia of the Alzheimer's type. Fully updated to reflect the latest findings on the NMDA receptor antagonist memantine.
Packed with practical information that is easy to access via detailed tables and charts, this pocket-sized volume (it literally fits into a lab coat or jacket pocket) is designed to be immediately useful for students, residents, and clinicians working in a variety of treatment settings, such as inpatient psychiatry units, outpatient clinics, consultation-liaison services, and private offices.

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If you prescribe for patients with arrhythmias, you will want to keep this valuable paperback close at hand. The Second Edition of this valuable reference responds to changes in the available medications as well as in the way they are currently used.



The book reviews everything you need to understand and prescribe today’s antiarrhythmic drugs:


mechanisms of cardiac arrhythmias and how antiarrhythmic drugs alter those arrhythmias, including common adverse effects
which factors to consider in using these drugs for treatment of supraventricular tachyarrhythmias, ventricular arrhythmias, and arrhythmias in pregnancy
a detailed review of atrial fibrillation to help you make decisions for patient management in this complicated area


Dr. Fogoros considers all the most recent drugs, plus promising drugs under investigation, to give you a full picture of therapeutic options. With Antiarrhythmic Drugs: A Practical Guide, Second Edition, you will have dependable information on how each drug works and when each one is indicated so you can give your patients the best possible treatment.

Drug hypersensitivities are immune-mediated reactions characterized by exanthems, fever and internal organ involvement. They represent a challenging field of research: many different drugs can induce a variety of clinical symptoms through multiple mechanisms of drug-host interaction, many of which are poorly understood. This is the first book to approach the phenomenon of drug hypersensitivity in a comprehensive manner. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in the book. Furthermore, the book covers clinical manifestations and new diagnostic methods, and introduces some recently established animal models. Well-accepted and also completely new concepts are presented and discussed in detail. Many topics are treated from multiple perspectives, and the 33 chapters are thoroughly cross-referenced. This publication will be of immense value not only to allergologists, dermatologists and anyone prescribing medication, but also to scientists in a pharmaceutical industry challenged by the economic effects of failures in drug development or drug removal from the market. Elucidating the mechanisms of drug hypersensitivity will not only help to identify patients at risk but will also provide novel insights into the pathophysiology of numerous immune-mediated diseases.

Cancer vaccine development has changed from a small-scale academic enterprise in to an applied science requiring a large clinical research infrastructure. In this book, a team of expert contributors take a focused look at the hot emerging area of cancer vaccines and tumor immunity. Cancer Vaccines and Tumor Immunity serves a unique role in that it presents as a continuum the basic science discoveries that have moved forward into clinical trials. It is a one-stop, concise reference for all those interested in cancer vaccines, summarizing where we have come from, demonstrating what we are currently doing, and identifying the next major advances.
Discusses how our new and developing understanding of T-regulatory cells and autoimmunity will impact cancer vaccine design
Offers a unique look forward into how vaccination in the context of bone marrow transplantation will open new avenues for clinical study
Offers an exceptional presentation of how modern genomic analysis of normal and tumor tissue will help to identify the next generation of cancer vaccine targets

Designed to provide quick access to the standards with which to fight infectious disease by focusing on selection, proper doses, costs, and side effects of antimicrobial agents, the 2004 Pocket Book of Infectious Disease Therapy draws extensively from recommendations made by the Centers for Disease Control, the Medical Letter, the American Hospital Formulary Service, and the AMA's Drug Evaluations. Tabular material has been updated to include all newly approved antibiotics, as well as new recommendations for management.

Johns Hopkins Univ. School of Medicine, Baltimore, MD. Annual pocket-sized reference provides standards of care for the management of infectious diseases with particular emphasis on antimicrobial agents, their selection, dosing regimens, costs, and side effects. Features numerous tabular tables. For physicians and residents.

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Several antiepileptic drugs (AEDs) now have pharmaceutical usage for treating bipolar disorder. There is growing evidence that AEDs have mood-stabilizing effects. This book is the first comprehensive, clinically oriented, reference on the use of AEDs to treat a variety of psychiatric disorders such as anxiety disorders, substance use disorders, eating disorders, personality disorders, and neuropsychiatric disorders.

Reported by the WHO and the World Bank to be the fourth cause of disability worldwide, depression can best be explained from a genetic perspective as a complex disorder of gene-environment interactions.
This is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches. In addition, the book covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.

This book is a classic, but you will be very hard up to find it anywhere as it is long out of print. If you have an interest in the science of this topic regardless of whether it is medical or athletic it is a must have. Dr. Vida really put a lot of research and useful explanations in this one. Highly suggested reading.

This book reviews the use of antiepileptic drugs focusing on the interactions between these drugs and between antiepileptics and other drugs. These interactions can be beneficial or can cause harm. The aim of this book is to increase awareness of the possible impact of combination pharmacotherapies. Pharmacokinetic and pharmacodynamic interactions are discussed supported by clinical and experimental data. The book consists of five sections covering the general concepts and advantages of combination therapies, the principles of drug interactions, the mechanisms of interactions, drug interactions in specific populations or in patients with co-morbid health conditions, and concludes with a look at the future directions for this field of research. The book will be of interest to all who prescribe antiepileptics to epileptic and non-epileptic patients, including epileptologists, neurologists, neuro-pediatricians , psychiatrists and general practitioners.


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Focusing on pharmaceutical agents that have advanced to Phase II of clinical testing or that hold significant promise in the field of therapeutics, this up-to-date resource provides a comprehensive review of the basic mechanisms, clinical developments, and applications of new therapeutic agents in thrombosis and thrombolysis.